The Chiang Lab - Create. Innovate. Discover.
Who We Are
罢丑别鈥�Chiang Laboratory, directed by鈥�Dr. Austin W.T. Chiang, is part of the Immunology Center of Georgia at 51暗网. Our lab is dedicated to advancing the frontiers of鈥�bioinformatics, AI/ML, and systems immunology, with a strong emphasis on translational research.
Dr. Chiang is a鈥痗omputational biologist鈥痺ith expertise spanning biomedical informatics, multi-omics integration, and systems immunology. He received his Ph.D. from National Yang-Ming University in Biomedical Informatics and Systems Biology, and completed postdoctoral training at Academia Sinica and the University of California, San Diego. Before joining 51暗网 in 2023, he served as an Assistant Project Scientist at UC San Diego.
Over the course of his career, Dr. Chiang has authored more than鈥�50 scientific manuscripts, filed鈥痵ix patents, and collaborated widely with international leaders in immunology, systems biology, and biotechnology. His research bridges鈥痜undamental discovery science鈥痺ith鈥痑pplied biomedical innovation, particularly in the areas of immune regulation, therapeutic protein engineering, and computational drug discovery.
Austin W.T. Chiang, PhD
Assistant Professor
Immunology Center of Georgia
Jump to: What We Study Research Team Current Research Interests Publications
What We Study
The overarching mission of our lab is to understand how the immune system functions across different diseases and to leverage鈥痗omputational and experimental strategies鈥痜or new therapeutic insights. We combine鈥痵ingle-cell multi-omics, AI-based predictive modeling, and systems biology frameworks鈥痶o investigate immune regulation, disease pathogenesis, and biomanufacturing.
Our research focuses on:
- Cardiovascular Immunology: Dissecting how immune tolerance breaks down in atherosclerosis and coronary artery disease, and identifying immune subsets that drive chronic vascular inflammation.
- Vaccine and Infection Biology: Investigating mechanisms of鈥�Staphylococcus aureus-mediated vaccine interference and identifying new pathways for effective vaccine development.
- Allergy and Autoimmunity: Studying eosinophilic esophagitis, systemic lupus erythematosus, and sarcoidosis to define molecular drivers of disease progression and therapeutic resistance.
- AI in Drug Discovery: Using advanced machine learning to develop predictive models for therapeutic design, early diagnostics, and vaccine strategies.
- Biomanufacturing and Glycobiology: Engineering mammalian cells and glycosylation pathways to improve therapeutic protein production and quality.
Research Team
The Chiang Lab is a鈥痬ultidisciplinary and collaborative environment鈥痶hat blends computational biology with experimental immunology.
- Principal Investigator:
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- Dr. Austin W.T. Chiang鈥�� Assistant Professor, Immunology Center of Georgia, Augusta University.
- Postdoctoral Fellows: Conducting advanced research in T cell biology and single cell multi-omics integration.
- Graduate Students and Trainees: Pursuing projects in systems immunology, bioinformatics pipeline development, and human immunological disease modeling.
- Research Staff and Collaborators: Supporting immunological data analysis, big data analysis, and biomanufacturing initiatives.
We foster an environment of鈥痠nnovation, mentorship, and collaboration, and maintain active partnerships with researchers across the United States and internationally.
Current Research Interests
Immune Regulation in Cardiovascular Disease
- Single-cell analysis of T cell subsets in coronary artery disease.
- Mechanistic studies of immune tolerance and vascular inflammation.
Vaccine Failure and Pathogen Immunity
- 贰濒耻肠颈诲补迟颈苍驳鈥�S. aureus-driven pathways that impair vaccine efficacy.
- Identifying molecular targets for next-generation vaccine design for human immunological diseases.
Allergic and Autoimmune Disorders
- Molecular profiling of human immunological diseases to uncover diagnostic biomarkers and therapeutic targets.
- driving chronic immune activation.
Artificial Intelligence for Drug Discovery
- Development of computational classifiers and predictive models for complex diseases such as CVD and cancer.
- AI-driven analysis of transcriptomics, lipidomics, and glycomics datasets to accelerate drug discovery.
Systems Biology of Biomanufacturing
- Engineering Chinese Hamster Ovary (CHO) cells for higher-yield, higher-quality therapeutic proteins.
- Systems-level analysis of glycosylation and secretory pathways for improved protein therapeutics.
Publications
- Roy, P., Bellapu, A., Suthahar, S.S.A., Oliaeimotlagh, M., Lyu, Q., Parashar, S., Makings, J., Wu, R., Kumar, S., Mehta, M.,鈥�Chiang, A.W.T., Sette, A., McNamara, C.A., Ley, K.鈥�Loss of effector Treg signature in APOB-reactive CD4鈦� T cells in patients with coronary artery disease.鈥�Nat Cardiovasc Res.鈥�2025.
- Jumabay, M., Abud, E.M., Okamoto, K., Dutta, P.,鈥�Chiang, A.W.T., et al.鈥�Eosinophilic Esophagitis Drives Tissue Fibroblast Regenerative Programs Towards Pathologic Dysfunction.鈥�J Allergy Clin Immunol.鈥�2025.
- Tsai, C.M., Hajam, I.A., Caldera, J.R.,鈥�Chiang, A.W.T., et al.鈥�Pathobiont-driven antibody sialylation through IL-10 undermines vaccination.鈥�J Clin Invest.鈥�2024.
- Pessentheiner, A.R., Spann, N.J., Autran, C.A., Ramms, B.,鈥�Chiang, A.W.T., et al.鈥�The Human Milk Oligosaccharide 3-Sialyllactose Promotes Inflammation Resolution and Reduces Atherosclerosis Development in Mice.鈥�JCI Insight.鈥�2024.
- Kulakova, L., Li, K.H.,鈥�Chiang, A.W.T., et al.鈥�Glycoengineering of the hepatitis C virus E2 glycoprotein improves biochemical properties and enhances immunogenicity.鈥�NPJ Vaccines.鈥�2025.